The drama explores themes in Christianity, culture and Philippine mythology such as aswang (fearsome, vampire-like shape-shifters), and tagapagbantay, the Philippine version of guardian angels (similar to their depiction in the drama, 100 Days to Heaven). The protagonist's name is derived from the Philippine national personification. Juan dela Cruz (Coco Martin) is the son of the mortal, Amelia (Mylene Dizon), and is is the latest successor to a line of tagapagbantay. His mother died giving birth to him, leaving the child in the care of Father Cito (Jaime Fabregas), the town's curé. Unbeknownst to Juan, he also has aswang blood from his demon father, Samuel (Albert Martinez); should the aswang know of this fact, they will force him to join their ranks.
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